Abstract
Synthesis and biological evaluation of a novel fluorinated tryptamine analogue are described. This new compound 1-(4-fluoro-5-methoxyindol-3-yl)pyrrolidine (2) was found to be a potent serotonin 5-HT1A agonist.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Fluorides / chemistry*
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Indoles / chemical synthesis
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Indoles / chemistry
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Indoles / pharmacology*
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Pyrrolidines / chemical synthesis
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Pyrrolidines / chemistry
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Pyrrolidines / pharmacology*
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Receptors, Serotonin / metabolism*
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Receptors, Serotonin, 5-HT1
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Serotonin Receptor Agonists / chemical synthesis
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Serotonin Receptor Agonists / chemistry
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Serotonin Receptor Agonists / pharmacology*
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Tryptamines / chemistry*
Substances
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1-(4-fluoro-5-methoxyindol-3-yl)pyrrolidine
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Indoles
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Pyrrolidines
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT1
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Serotonin Receptor Agonists
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Tryptamines
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tryptamine
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Fluorides